CNI continues to be actively engaged in key areas of standards and infrastructure development. The Coalition is particularly concerned with facilitating the difficult and delicate transition of standards and technologies into operational infrastructure for the research, higher education and library communities. In addition to the specific program initiatives described here, CNI participates in and tracks a wide range of developments in areas as diverse as identifiers, digital books, metadata standards, distributed and federated network services, harvesting technologies, recommender systems, and personalization technologies. As we look at an evolving landscape that includes commercial Web search engines, traditional library automation tools such as online catalogs, stand-alone abstracting and indexing databases, systems deployed by scholarly publishers, museums, and other content providers, and learning management systems, the Coalition is concerned with architectural and standards frameworks that can facilitate integration and interoperation. This perspective has motivated much of our work over the last few years on cyberinfrastructure, IRs, the various components of the Open Archives Initiative (including the protocol for metadata harvesting, the object reuse and exchange protocol, and, most recently, the Open Annotation work), and learning management systems. Currently, we see a number of trends that we believe will drive a renewed focus on standards and infrastructure, including the proliferation of mobile devices (smart phones, tablets, e-book readers), the move towards data resources as part of the infrastructure (changes in identity, bibliographic control, etc.), and the move towards cross-institutional systems (Web-scale discovery and resource sharing, cloud computing, and distributed storage). Many of them couple technical issues with policy challenges in novel ways. We have been exploring the issues in these areas through articles and presentations, executive roundtables and other programming at our membership meetings, and participation in a range of committees and advisory boards.